(Antigen Release Agent and Checkpoint inhibitor)
Nanoparticle co-delivering a kinase inhibitor and immunotherapy to kill cancer cells and unleash the power of the immune system
ARAC™ reduces the effective dose of drugs by 5-fold in a metastatic lung tumor model and the effect is immune (CD8) mediated.
Adjuvant loaded ARAC™ leads to cure of lung cancer in mice.
ARAC™ kills cancer and renders PDL1 low tumors responsive to immunotherapy
Reda, M., Ngamcherdtrakul, W., Nelson, M.A., Siriwon, N., Wang, R., Zaidan, H.Y., Bejan, D.S., Reda, S., Hoang, N.H., Crumrine, N.A., Rehwaldt, J.C., Bindal, A., Mills, G.B., Gray, J.W., Yantasee, W. Development of novel immunotherapy based on nanoparticle co-delivering PLK1 and PD-L1 inhibitors for lung cancer treatment. 2021, PREPRINT | View Online