Nanoparticle (PDX-NPTM) loaded with siRNA against heat-shock protein 47 (HSP47).
siHSP47-NP effectively reduced HSP47 protein expression in a bleomycin-induced scleroderma (skin fibrosis) mouse model.
The antioxidant mesoporous silica core also played a prominent role in reducing pro-fibrotic markers and skin thickness of the mice.
siHSP47-NP resulted in the reduction of dermal thickness by 19% (p≤0.01 vs. bleomycin alone), which brought the value down to the untreated level (p=0.38).
Morry J, Ngamcherdtrakul W, Gu S, Goodyear SM, Castro DJ, Reda MM, Sangvanich T, Yantasee W. Dermal delivery of HSP47 siRNA with NOX4-modulating mesoporous silica-based nanoparticles for treating fibrosis. Biomaterials. 2015 Oct;66:41-52. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522385/