(Nanoparticle-based Augmenting Immune Response and Inhibiting Suppressive Environment of tumors)
For the CO-DELIVERY of selected therapeutics (siRNA and adjuvant) to trigger anti-tumor immune response.
AIRISE utilizes a local treated local tumor as a depot for neo-antigens in situ to trigger adaptive immunity (cytotoxic T cells) that kills tumors everywhere in the body.
AIRISE is an off-the-shelf drug with personalized effect without tedious neoantigen identification in conventional vaccines.
In-situ tumor vaccination triggers adaptive immune response.
AIRISE improves the effect of checkpoint inhibitors and raises survival rate.
Only 3 doses of AIRISE are effective in bilateral melanoma mouse model.
Both tumors were substantially reduced; owing to CD8+ T cell response (confirmed by CD8 depletion).
Mice were cured and were tumor-free for > 17 months even after tumor rechallenge, indicating memory T cell effect.