Science

Core Technology

Nanoparticle platform:

–  Capable of loading multiple cargo types ( siRNA, drugs, vaccines, and/or immunotherapies) at once to harness their synergy while keeping uniformly small size (100 nm).

–  Same recipe for loading of each cargo type, yielding consistent materials without re-optimization. 

– Capable of targeted delivery of these cargos to solid tumors upon intravenous administration

– Capable of delivering to both cancer and antigen presenting cells (DCs and macrophages)

– siRNA is loaded last by few min manual shaking, facilitating personalized medicine.

– Multiple siRNAs for multiple gene targets can be loaded on the same nanoparticles, overcoming cancer resistance to one targeted therapy.  

CANCER VACCINE STRATEGY WITH AIRISE™ AND ARAC™ (SEE PIPELINE PAGE)

Guo et al Front. Immunol 2018

Video 1.  Schematic of nanoparticle platform for siRNA and drug delivery.